In-vitro Experimental Characterization of the Transmantle Pressure in the Cerebral Aqueduct

  • Moral-Pulido, Francisco (Universidad de Jaén)
  • Sincomb, Stephanie (University of California- San Diego)
  • Campos, Obed (University of California - San Diego)
  • Martínez-Bazán, Carlos (Unversidad de Granada)
  • Haughton, Victor (University of Wisconsin)
  • Sánchez, Antonio (University of California- San Diego)

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The present work aims at characterizing the transmantle pressure Δp(t), being the instantaneus pressure difference between the lateral ventricles and the cerebral subarachnoid space. This pressure drop reaches its largest value in the cerebral aqueduct, a narrow canal which connects the third and fourth ventricles. This dynamic phenomenon, relevant to understand ventriculomegaly in cases of normal pressure hydrocephalus (NPH), is difficult to characterize from in-vivo measurements. Therefore, in-vitro experiments, involving an MRI-informed experimental model of the cerebral aqueduct flow, are performed here to determine the transmantle pressure and its corresponding phase lag with the flow rate. The experimental results are in good agreement with those provided by the analytical model developed by Sincomb et al. (2020).